HDAC3-IN-4

SKU: orb2663912

Description

HDAC3-IN-4 is a potent, orally bioavailable, and selective HDAC3 inhibitor (IC50 = 89 nM) that promotes PD-L1 degradation via lysosomal cathepsin B modulation (DC50 = 5.7 µM). Its selectivity over other HDAC isoforms supports its utility in cancer immunotherapy research, both in vitro and in vivo, for investigating immune checkpoint regulation.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 2988762-46-3
• MW: 423.53
• Formula: C₂₂H₂₅N₅O₂S
• SMILES: O=C(NCC1=CC=C(C=C1)C(=O)NNCCC)C2=NC=C(S2)CNC=3C=CC=CC3

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172419442