HDAC1/6-IN-3

SKU: orb3136351

Description

HDAC1/6-IN-3 is an effective HDAC inhibitor with significant inhibitory effects on HDAC1 (IC50= 1.1 nM) and HDAC6 (IC50= 2.7 nM). In HepG2 cells, it causes cell cycle arrest at the G0/G1 phase and induces apoptosis and pyroptosis. Furthermore, HDAC1/6-IN-3 demonstrates notable antitumor activity in HepG2 tumor xenograft models. This compound is applicable for cancer research, including studies on liver, lung, colon, and breast cancers.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Molecular Biology

Key Properties

• CAS Number: 3038691-85-6
• MW: 453.55
• Formula: C₂₄H₂₇N₃O₄S
• SMILES: O=C(NO)CCCCCC(=O)N(C1=CC=C(OC)C=C1)CC=2N=C(SC2)C=3C=CC=CC3
• Target: HDAC,Pyroptosis,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

HDAC,Pyroptosis,Apoptosis