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HDAC1-IN-12

SKU: orb3174786

Description

HDAC1-IN-12 is an inhibitor of the malignant malaria parasite (Plasmodium falciparum) HDAC1 (PfHDAC1), with an IC50 of 4.1 nM. This inhibitor functions by inhibiting PfHDAC1, increasing histone H3 acetylation in the P. falciparum parasite, and reducing the expression of genes associated with malaria invasion. It exhibits favorable safety profiles, improved physicochemical properties, and effective in vivo antimalarial activity, making HDAC1-IN-12 a valuable tool for malaria research.

Research Area

Epigenetics & Chromatin, Infectious Disease & Virology, Molecular Biology

Images & Validation

Key Properties

TargetParasite,HDAC

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information