HDAC1-IN-10

SKU: orb3175137

Description

HDAC1-IN-10 (Compound 2b) is a potent, selective, and orally active inhibitor of HDAC1 and HDAC2, with IC50 values of 6 nM and 190 nM, respectively. It exhibits IC50 values greater than 50 μM against HDAC3-8. This compound effectively inhibits the proliferation of HCT-116 cells with a GI50 of 155 nM and suppresses tumor growth in HCT-116 colon cancer xenograft models in nude mice. HDAC1-IN-10 is applicable for colon cancer research.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 849233-98-3
• MW: 458.54
• Formula: C₂₅H₂₂N₄O₃S
• SMILES: O=C(OCC=1C=NC=CC1)NCC2=CC=C(C=C2)C(=O)NC=3C=C(C=CC3N)C=4SC=CC4
• Target: HDAC

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

HDAC