HDAC-IN-91

SKU: orb3135737

Description

HDAC-IN-91 is a multi-target inhibitor affecting HDAC [HDAC1 (IC50= 134.22 nM), HDAC2 (IC50= 66.29 nM)], carbonic anhydrase [CA IX (KI= 72.03 nM), XII (KI= 50.76 nM)], and tubulin polymerization (IC50= 2.56 μM). It inhibits PARP1 and increases the Bax/Bcl-2 ratio. The compound causes cell cycle arrest at the G2/M phase and triggers apoptosis through mitochondrial pathways. By inhibiting tubulin polymerization, HDAC-IN-91 exhibits potent cytotoxic activity. This compound is applicable in research on breast cancer, colorectal cancer, cervical cancer, and lung cancer.

Research Area

Cell Biology, Epigenetics & Chromatin, Metabolism Research, Molecular Biology, Protein Biochemistry, Signal Transduction

Key Properties

• Target: Caspase,HDAC,Bcl-2 Family,PARP,Microtubule Associated,Carbonic Anhydrase,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Caspase,HDAC,Bcl-2 Family,PARP,Microtubule Associated,Carbonic Anhydrase,Apoptosis