HDAC-IN-7

SKU: orb1306715

Description

HDAC-IN-7 is a synthetic histone deacetylase (HDAC) inhibitor structurally related to Tucidinostat. It reduces histone H3 acetylation and triggers apoptotic cell death in vitro, as demonstrated in human colon cancer models, supporting its use in oncology research.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 743420-02-2
• MW: 390.41
• Purity: 98.45% (May vary between batches)
• Formula: C₂₂H₁₉FN₄O₂
• SMILES: N(C(=O)C1=CC=C(CNC(C=CC=2C=CC=NC2)=O)C=C1)C3=C(N)C=CC(F)=C3
• Target: HDAC
• Solubility: DMSO:55 mg/mL (140.88 mM)

Bioactivity

• Target IC50:
  HDAC2:160nM|HDAC10:78 nM|HDAC8:733nM|HDAC1:95nM|HDAC3:67nM|HDAC11:432 nM

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Chidamide impurity, CS055, CS055, CS-055, CS 055, HBI 8000, HBI8000, HBI-8000, HDACIN7, HDAC-IN-7, HDAC8, HDAC3, HDAC2, HDAC IN 7, HDAC1, HBI-8000, HDAC

Compound Identifiers

PubChem CID

53394037