HDAC-IN-51

SKU: orb1744375

Description

HDAC-IN-51 is a potent and selective small molecule inhibitor of histone deacetylase (HDAC) enzymes. It is a valuable research tool for investigating epigenetic mechanisms in cancer biology and has demonstrated utility in both cellular assays and in vivo preclinical studies.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• MW: 436.51
• Purity: 97.19% (May vary between batches)
• Formula: C₂₇H₂₄N₄O₂
• SMILES: O=C(NC1=CC=C(C(NC2=CC=CC=C2N)=O)N=C1)C(C3=CC=CC=C3)CC4=CC=CC=C4
• Target: CDK,HDAC,Bcl-2 Family,Apoptosis
• Solubility: DMSO:45 mg/mL (103.09 mM)

Bioactivity

• Target IC50:
  HDAC2:0.431 μM|HDAC1:0.353 μM|HDAC11:85.4 μM|HDAC10:0.32 Μm|HDAC3:0.515 μM
• In Vitro:
  HDAC-IN-51 (compound 8d) (1 nM-10 μM; 48 h) has antiproliferative activity with IC50 values of 0.54, 0.56, and 1.35 μM against K562, HCT116, and A549 cells, respectively. HDAC-IN-51 (1, 5 μM; 24, 48 h; U937 leukemia cells) arrests the cell cycle in the G1 phase. HDAC-IN-51 (1, 5 μM; 48 h; U937 cells) induces apoptosis and downregulates miRNAs with anti-apoptotic activity (miR-17-5p, miR-18-5p, miR-19b-3p, miR-20a-5p and miR-21-5p). HDAC-IN-51 (1, 5 μM; 48 h; U937 cells) increases the mRNA expression of p21, BAX, and BAK and downregulates cyclin D1 and BCL-2.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HDAC

Compound Identifiers

PubChem CID

166642399