HDAC-IN-50

SKU: orb1744377

Description

HDAC-IN-50 is a potent, orally bioavailable dual inhibitor of FGFR and HDAC enzymes, demonstrating low nanomolar IC50 values. It exhibits anti-tumor activity by inducing apoptosis and G0/G1 cell cycle arrest, concurrently reducing levels of pFGFR1, pERK, and pSTAT3 in cellular models. This profile supports its investigation in oncology research, particularly for cancers driven by FGFR signaling and epigenetic dysregulation.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 2653339-26-3
• MW: 575.7
• Formula: C₃₁H₄₁N₇O₄
• SMILES: N(CCNC(C)C)(C1=CC2=C(C=C1)N=CC(=N2)C3=CN(CCCCCCC(NO)=O)N=C3)C4=CC(OC)=CC(OC)=C4
• Target: HDAC,Others,Apoptosis,FGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

166642476