HDAC-IN-40

SKU: orb1689829

Description

HDAC-IN-40 is a potent alkoxyamide-based inhibitor with high affinity for HDAC2 (Ki=60 nM) and HDAC6 (Ki=30 nM). It exhibits antitumor activity and is a valuable chemical probe for epigenetic and oncology research in both cellular and animal models of cancer.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 2463198-51-6
• MW: 326.35
• Purity: 99.01% (May vary between batches)
• Formula: C₁₅H₂₂N₂O₆
• SMILES: COc1cc(OC)cc(c1)C(=O)NOCCCCCC(=O)NO
• Target: HDAC
• Solubility: DMSO:200 mg/mL (612.84 mM)

Bioactivity

• Target IC50:
  HDAC4:49200 μM (Ki)|HDAC2:60 nM (Ki)|HDAC6:30 nM (Ki)|HDAC8:5690 nM (Ki)
• In Vitro:
  HDAC-IN-40 shows antiproliferative activity against the cell line A2780 and Cal27 with IC50 values of 0.89 µM and 0.72 µM, respectively. HDAC-IN-40 induces accumulation of acetyl α-tubulin in Cal27 and Cal27CisR. HDAC-IN-40 enhances the Cisplatin-induced cytotoxicity via caspase-3/7 activation.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HDACIN40, HDAC-IN-40, HDAC IN 40, HDAC2, HDAC6

Compound Identifiers

PubChem CID

156019761