hCAIX-IN-5

SKU: orb1689284

Description

hCAIX-IN-5 is a selective inhibitor of carbonic anhydrase IX (hCAIX), exhibiting Ki values of 829.1 nM for hCAIX and 130.7 nM for hCAIV, with minimal activity against hCAI/II (>10000 nM). This compound is a valuable research tool for studying tumor metabolism and hypoxia in cancer models, both in vitro and in vivo.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2451479-57-3
• MW: 309.29
• Purity: 99.26% (May vary between batches)
• Formula: C₁₈H₁₂FNO₃
• SMILES: N(C(/C=C/C1=CC=C(F)C=C1)=O)C=2C=C3C(=CC2)OC(=O)C=C3
• Target: Carbonic Anhydrase
• Solubility: DMSO:20 mg/mL (64.66 mM)

Bioactivity

• Target IC50:
  CA IX (human):829.1 nM|CA IV (human):130.7 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CarbonicAnhydrase, Carbonic Anhydrase, hCAII, hCAI

Compound Identifiers

PubChem CID

84223908