hCAII-IN-9

SKU: orb1744379

Description

hCAII-IN-9 is a potent small molecule inhibitor of human carbonic anhydrase isoforms II, IX, and XII, with respective IC50 values of 1.18 µM, 0.17 µM, and 2.99 µM. It is not permeable to the blood-brain barrier, making it a useful research tool for studying the roles of these enzymes in peripheral physiological and pathological processes, such as tumorigenesis and acid-base regulation, in vitro.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2878477-18-8
• MW: 417.89
• Purity: 99.87% (May vary between batches)
• Formula: C₁₅H₁₆ClN₃O₅S₂
• SMILES: S(N)(=O)(=O)C1=C(NC(=O)C2=CC(C)=CC(C)=C2)C=C(Cl)C(S(N)(=O)=O)=C1
• Target: Carbonic Anhydrase
• Solubility: DMSO:55 mg/mL (131.61 mM)

Bioactivity

• Target IC50:
  CA IX (human):0.17 μM|CA XII (human):2.99 μM|CA II (human):1.18 μM
• In Vitro:
  HCAII-IN-9 (Compound 11) (100 μM; 24-48 h) inhibits BHK-21 and HEK-293 cells with cell viability of 48% and 72%, respectively.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CA XII, Carbonic anhydrase IX, CarbonicAnhydrase, Carbonic anhydrase II, Carbonic Anhydrase

Compound Identifiers

PubChem CID

166642393