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HC-067047

SKU: orb1302659

Description

HC-067047

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number883031-03-6
MW471.51
Purity99.89%
FormulaC26H28F3N3O2
SMILESCc1c(cc(-c2ccccc2)n1CCCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F
TargetTRP/TRPV Channel
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.24 mM);DMSO:25 mg/mL (53.02 mM)

Bioactivity

Target IC50
TRPV4 (human):8 ± 6 nM|TRPV4 (rat):133 ± 25 nM|TRPV4 (mouse):17 ± 3 nM
In Vivo
HC-067047 caused a significant reduction o the maximal micturition pressure in rats, which might be caused by an effect on TRPV4 in smooth musclee.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

HC 067047, HC067047, HC-067047, hTRPV4, Inhibitor, inhibit, mTRPV4, TRP Channel, TRPVChannel, TRPV Channel, TRPChannel, Transient receptor potential channels

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Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

HC-067047 (orb1302659)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 70.00
1 ml x 10 mM (in DMSO)
$ 110.00
5 mg
$ 110.00
10 mg
$ 140.00
25 mg
$ 240.00
50 mg
$ 370.00
100 mg
$ 570.00
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