HC-067047

SKU: orb1302659

Description

HC-067047 is a potent and selective antagonist of the TRPV4 ion channel, effectively blocking its activation by endogenous agonists like 4α-PDH. This small molecule is a valuable research tool for investigating TRPV4's role in pain, inflammation, and osmoregulation in both cellular and animal models.

Research Area

Neuroscience

Key Properties

• CAS Number: 883031-03-6
• MW: 471.51
• Purity: >98%
• Formula: C₂₆H₂₈F₃N₃O₂
• SMILES: Cc1c(cc(-c2ccccc2)n1CCCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F
• Target: Ion channel
• Solubility: Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml).

Bioactivity

• Target IC50:
  TRPV4 (human):8 ± 6 nM|TRPV4 (rat):133 ± 25 nM|TRPV4 (mouse):17 ± 3 nM
• In Vivo:
  HC-067047 caused a significant reduction of the maximal micturition pressure in rats, which might be caused by an effect on TRPV4 in smooth muscle.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HC 067047, HC067047, HC-067047, hTRPV4, Inhibitor, inhibit, mTRPV4, TRP Channel, TRPVChannel, TRPV Channel, TRPChannel, Transient receptor potential channels

Compound Identifiers

PubChem CID

2742550