HBDDE

SKU: orb1691619

Description

HBDDE is a selective inhibitor of PKCα and PKCγ isoenzymes (IC50 43 μM and 50 μM, respectively), derived from ellagic acid. It demonstrates pro-apoptotic activity in neuronal cells and is used in research to study PKC signaling in neuroscience and cancer biology.

Research Area

Cell Biology, Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 154675-18-0
• MW: 338.31
• Purity: 99.99% (May vary between batches)
• Formula: C₁₆H₁₈O₈
• SMILES: C(OC)C1=C(C(O)=C(O)C(O)=C1)C2=C(COC)C=C(O)C(O)=C2O
• Target: Apoptosis,PKC
• Solubility: H2O:0.9 mg/mL (2.66 mM);DMSO:4.5 mg/mL (13.3 mM);Ethanol:0.9 mg/mL (2.66 mM)

Bioactivity

• Target IC50:
  PKCγ:50 μM (IC50)|PKCα:43 μM (IC50)
• In Vitro:
  HBDDE (50 μM; 5 h; Cerebellar granule cells) leads to a substantial reduction in cell viability by approximately 70%. Additionally, HBDDE demonstrates a notable augmentation in caspase-3 activity.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HBDDE, Apoptosis, PKCα, PKCβ1, PKCγ, PKCδ

Compound Identifiers

PubChem CID

3568