Harringtonine

SKU: orb1299065

Description

Harringtonine is a natural alkaloid with potent antitumor and antiviral properties, functioning as an inhibitor of both DNA and protein synthesis with particular efficacy against S-phase cells. It is widely used in cancer research, demonstrating activity in both in vitro cell culture studies and in vivo animal models of leukemia and solid tumors.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 26833-85-2
• MW: 531.59
• Purity: 99.88%
• Formula: C₂₈H₃₇NO₉
• SMILES: COC(=O)C[C@](O)(CCC(C)(C)O)C(=O)O[C@H]1[C@H]2c3cc4OCOc4cc3CCN3CCC[C@]23C=C1OC
• Target: Influenza Virus
• Solubility: DMSO:55 mg/mL (103.46 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.76 mM)

Bioactivity

• Target IC50:
  HeLa cells:4 μM|CHIKV:0.24 μM (EC50)|HSV1:0.1081-0.1584 μM|HL-60 cells:0.047 μM|BHK-21 cells:0.24 μM (EC50)
• In Vivo:
  METHODS: To study in vivo activity, Harringtonine (0.5-4 mg/mouse) was injected retroorbital into C57BL/6 mice. RESULTS: Within 5 min, Harringtonine completely depleted multimers in all organs except testis and brain, and it took up to 30 min to significantly reduce the number of multimers due to the blood-brain and blood-testis barriers.
• In Vitro:
  Harringtonine inhibits the elongation phase of translation by preventing substrate binding to the acceptor site on the 60-S ribosome subunit, blocking aminoacyl-tRNA binding and peptide bond formation . It displays potent inhibition of Chikungunya virus infection (EC50: 0.24 μM) and could inhibit other alphaviruses . Additionally, Harringtonine inhibits the growth of human myeloid leukemia cells in vitro at low concentrations .

Storage & Handling

• Storage: keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, InfluenzaVirus, Influenza Virus, Harringtonine

Compound Identifiers

PubChem CID

276389