Harmaline hydrochloride

SKU: orb1298647

Description

Harmaline hydrochloride is a fluorescent beta-carboline alkaloid and a partially hydrogenated derivative of harmine. It is widely used in neuroscience research, particularly for studying tremor mechanisms, as it induces rhythmic firing in inferior olivary neurons in vivo.

Key Properties

• CAS Number: 363-11-1
• MW: 250.72
• Purity: 99.81% (May vary between batches)
• Formula: C₁₃H₁₅ClN₂O
• SMILES: CC1=NCCC2=C1NC3=C2C=CC(=C3)OC.Cl
• Target: Others
• Solubility: DMSO:27.5 mg/mL (109.68 mM);H2O:25.64 mg/mL (102.27 mM)

Bioactivity

• In Vivo:
  Harmaline could exert on antitumor activity with a dose of 15 mg/kg/day in vivo, which is related with cell cycle arrest.Harmaline also induces cognitive disturbances such as motor and spatial learning impairments. Lower doses of harmaline (5–10 mg/kg) have anxiogenic effects since higher doses (20 mg/kg) have anxiolytic-like properties.
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• In Vitro:
  Harmaline could up-regulate the expressions of cell cycle-related proteins of p-Cdc2, p21, p-p53, Cyclin B and down-regulate the expression of p-Cdc25C. In addition, Harmaline could up-regulate the expressions of Fas/FasL, activate Caspase-8 and Caspase-3.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Harmaline hydrochloride, Harmaline Hydrochloride, Harmidine Hydrochloride, Harmidine hydrochloride

Compound Identifiers

PubChem CID

196973