Handelin

SKU: orb1297537

Description

Handelin

Research Area

Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 62687-22-3
• MW: 552.66
• Purity: 99.35%
• Formula: C₃₂H₄₀O₈
• SMILES: [H][C@@]12CC[C@@](C)(O)[C@]34C[C@@]5(C(=O)O[C@@]6([H])[C@@]5([H])[C@H](C[C@@](C)(O)[C@]5([H])CC=C(C)[C@]65[H])OC(C)=O)[C@](C)(C=C3)[C@@]4([H])[C@]1([H])OC(=O)C2=C
• Target: NF-κB,Immunology/Inflammation related
• Solubility: DMSO:10 mg/mL (18.09 mM);10% DMSO+90% Corn Oil:1 mg/mL (1.81 mM)

Bioactivity

• In Vitro:
  The present study was designed to investigate the anti-inflammatory potential of Handelin in vitro and in vivo. Handelin inhibited LPS-stimulated production of NO and PGE2 in cultured mouse macrophage RAW 264.7 cells. The suppression of NO and PGE2 production by Handelin was correlated with the down-regulation of mRNA and protein expressions of iNOS and COX-2. Further study revealed that Handelin suppressed the induction of pro-inflammatory cytokines including TNF-α± and IL-1β as well as microRNA-155 in LPS-induced RAW264.7 cells. Activation of the transcriptional activity of NF-κB by LPS was also alleviated by Handelin, which was well coincided with its inhibitory effect on IκB degradation. In addition, the activation of MAPKs such as ERK and JNK signaling was suppressed by Handelin. In in vivo animal model, oral administration of Handelin inhibited carrageenan-induced paw edema and TPA-induced ear edema, respectively. The analysis of cytokine production in serum showed that Handelin dose-dependently inhibited the production of IL-1β in a carrageenan-induced paw edema.

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NF-κB, NFkB, NF-kB, NFκB, NO Synthase, Nuclear factor-κB, Nuclear factor-kappaB, Inhibitor, inflammation, Inflammation related, Inflammationrelated, Immunologyrelated, Immunology related, inhibit, Handelin, PGE, TNF-α

Compound Identifiers

PubChem CID

71448931