Halopemide

SKU: orb1308234

Description

Halopemide is a dual-activity small molecule, functioning as a potent inhibitor of phospholipase D (PLD) enzymes and as a dopamine receptor antagonist. This compound is utilized in neuroscience and cell signaling research, particularly in studies investigating psychotropic mechanisms and PLD-mediated pathways in both cellular and animal models.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 59831-65-1
• MW: 416.88
• Purity: 96.57% (May vary between batches)
• Formula: C₂₁H₂₂ClFN₄O₂
• SMILES: Fc1ccc(cc1)C(=O)NCCN1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O
• Target: Dopamine Receptor,Phospholipase
• Solubility: DMSO:55 mg/mL (131.93 mM)

Bioactivity

• Target IC50:
  PLD1:220 nM|PLD2:310 nM
• In Vivo:
  In the majority of monkeys tested, Halopemide (10 mg/kg; p.o.) causes dyskinesias.
• In Vitro:
  In transdifferentiated MOVAS cells, Halopemide (1-2 μM; 21 days) influences calcification.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Phospholipase, psychotropic, cells, DopamineReceptor, dopamine receptors, Dopamine Receptor, dyskinesias, calcification, cancer, PLD1, PLD2, inhibit, Halopemide, MOVAS, Inhibitor

Compound Identifiers

PubChem CID

65490