Halofuginone hydrobromide

SKU: orb1304120

Description

Halofuginone hydrobromide is a semisynthetic alkaloid that suppresses collagen type I and MMP-2 gene expression. This inhibition of key fibrotic and angiogenic promoters makes it a valuable research tool for studying fibroproliferative diseases, tumor stroma, and cancer progression in both cellular and animal models.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 64924-67-0
• MW: 495.59
• Purity: 99.73%
• Formula: C₁₆H₁₇BrClN₃O₃.HBr
• SMILES: Br.O[C@H]1CCCN[C@@H]1CC(=O)Cn1cnc2cc(Br)c(Cl)cc2c1=O
• Target: DNA/RNA Synthesis,Sodium Channel,Calcium Channel,Parasite,TGF-beta/Smad
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.04 mM);DMSO:17 mg/mL (34.3 mM)

Bioactivity

• Target IC50:
  Prolyl-tRNA synthetase:18.3±0.5 nM(ki)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RU 19110, RU19110, RU-19110, RU-19110 (hydrobromide), RNA Synthesis, RNASynthesis, prolyl-tRNA, prolyl-tRNA synthetase, ProRS, Smad, SodiumChannel, Sodium Channel, Stenorol, Tempostatin, TGF-b/Smad, TGFb, TGF-beta/Smad, TGFbeta/Smad, TGFbeta, TGF-beta, TGF-β/Smad, TGF-β, TGFβ, Transforming growth factor beta, type-I, Halofuginone, Halofuginone hydrobromide, Halofuginone Hydrobromide, Inhibitor, Parasite, Na+ channels, Na channels, osteoarthritis, inhibit, Ca channels, Ca2+ channels, Calcium Channel, CalciumChannel, collagen-1, collagen, DNA Synthesis, DNA/RNA Synthesis, DNASynthesis

Compound Identifiers

PubChem CID

11591339