HA-14-1

• Catalog Number: orb2283827
• Category: Small Molecules
• Description: HA-14-1, a small molecule, binds the surface pocket of Bcl-2 proteins (IC50= ~ 9 µM), including Bcl-xl and Bcl-W, and disrupts their interaction with the Bak peptide. This action induces apoptosis by activating Apaf-1 and caspase-9 and -3. Additionally, HA-14-1 effectively induces apoptosis in human acute myeloid leukemia (HL-60) cells, with a 50 µM concentration resulting in a 90% loss of cell viability.
• Purity: 98.00%
• MW: 409.2
• Biological Activity: HA-14-1, a small molecule, binds the surface pocket of Bcl-2 proteins (IC50= ~ 9 µM), including Bcl-xl and Bcl-W, and disrupts their interaction with the Bak peptide. This action induces apoptosis by activating Apaf-1 and caspase-9 and -3. Additionally, HA-14-1 effectively induces apoptosis in human acute myeloid leukemia (HL-60) cells, with a 50 µM concentration resulting in a 90% loss of cell viability.
• CAS Number: 927635-64-1
• Formula: C₁₇H₁₇BrN₂O₅
• SMILES: C(C(OCC)=O)(C#N)C1C=2C(OC(N)=C1C(OCC)=O)=CC=C(Br)C2
• Storage: -20°C
• Note: For research use only