H4 Receptor antagonist 1

SKU: orb1301452

Description

This compound is a potent and selective inverse agonist of the histamine H4 receptor, exhibiting an IC50 of 19 nM. It is a valuable research tool for investigating the role of the H4 receptor in immunological and inflammatory processes, suitable for both in vitro binding assays and in vivo disease model studies.

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 848217-00-5
• MW: 316.79
• Purity: 98.81% (May vary between batches)
• Formula: C₁₆H₁₇ClN₄O
• SMILES: CN1CCN(CC1)c1nc(C)nc2c3cc(Cl)ccc3oc12
• Target: Histamine Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.16 mM);DMSO:10 mg/mL (31.57 mM)

Bioactivity

• Target IC50:
  H4 receptor:19 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Histamine Receptor, HistamineReceptor, H4 receptor, H4 Receptor antagonist 1, H-4 Receptor antagonist 1, Inhibitor, inhibit

Compound Identifiers

PubChem CID

3934857