H3B-968

SKU: orb2278292

Description

H3B-968 is a potent, ATP-competitive inhibitor of the Werner syndrome helicase (WRN), exhibiting an IC50 of ~10 nM against its helicase activity. This small molecule is a valuable research tool for investigating synthetic lethality in microsatellite unstable (MSI) cancer models, both in cellular and in vivo studies.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 2912294-90-5
• MW: 548.46
• Formula: C₂₂H₁₈F₆N₄O₄S
• SMILES: S(NCC(NC1=CC=C(CC)C=C1)=O)(=O)(=O)C=2N=C(C=C(C(F)(F)F)N2)C3=CC=C(OC(F)(F)F)C=C3
• Target: DNA/RNA Synthesis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

168476124