H3B-616

SKU: orb2814901

Description

H3B-616 is a potent, allosteric CPS1 inhibitor (IC50 = 66 nM) targeting a synthetic lethal vulnerability in LKB1-deficient NSCLC. It disrupts pyrimidine synthesis and has demonstrated efficacy in relevant in vitro and in vivo cancer models for research use.

Key Properties

• CAS Number: 2468199-06-4
• MW: 409.45
• Formula: C₂₃H₂₄FN₃O₃
• SMILES: C(=O)(C=1C=C2C(=CC1)C=CN2)N3C[C@@H](C)N(C(=O)C4=C(F)C=C(OC)C=C4)[C@H](C)C3

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

156022190