H2L5186303

SKU: orb1305798

Description

H2L5186303 is a selective LPA2 receptor antagonist used in respiratory disease research. It serves as a pharmacological tool for investigating lysophosphatidic acid signaling in models of asthma, applicable in both in vitro cellular assays and in vivo preclinical studies.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 139262-76-3
• MW: 488.45
• Purity: 98.19% (May vary between batches)
• Formula: C₂₆H₂₀N₂O₈
• SMILES: OC(=O)\C=C/C(=O)Nc1ccc(Oc2cccc(Oc3ccc(NC(=O)\C=C/C(O)=O)cc3)c2)cc1
• Target: LPL Receptor,Apoptosis,LPA Receptor
• Solubility: DMSO:200 mg/mL (409.46 mM)

Bioactivity

• Target IC50:
  LPA2 receptor:9 nM (IC50)
• In Vivo:
  H2L5186303 shows strong suppressive efficacy when administered before OVA sensitization and challenge, such as suppression of airway hyper responsiveness, inflammatory cytokine levels, mucin production, and eosinophil numbers.
• In Vitro:
  The high cell invasion activity of HT1080-M6 cells is significantly suppressed by H2L5186303.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

H2L 5186303, H2L5186303, H2L-5186303, LPA Receptor, LPAReceptor, LPA2, ZINC 33388081, ZINC33388081, ZINC-33388081

Compound Identifiers

PubChem CID

90488981