H-Ras (G12V)GST

SKU: orb533590

Description

Ras proteins are members of the superfamily of small GTP-binding proteins that function as molecular switches controlling a variety of signaling and transport pathways. H-Ras is one of the classic human Ras proteins (H-, N-, K-Ras4A, and K-Ras4B). The mutation G12V leads to elimination of the intrinsic GTPase activity. H-Ras (G12V) is effective in activation of PI3K and PKB, whereas N-Ras and K-Ras are more potent towards MAP kinase. The GST-Tag facilitates the protein's application in typical GST pull-down assays.

Research Area

Signal Transduction

Key Properties

• Source: E. coli
• Biological Origin: human
• Purity: > 90% (SDS-PAGE)

Storage & Handling

• Storage: store at -80 °C
• Form/Appearance: liquid (Supplied in 25 mM Tris-HCl pH 7.5, 150 mM NaCl, 5 mM MgCl 2and 5 mM beta-mercaptoethanol)
• Expiration Date: 6 months from date of receipt.
• Dry Ice Shipping: Please note: This product requires shipment on dry ice. A dry ice surcharge will apply.
• Disclaimer: For research use only

Alternative Names

Harvey rat sarcoma viral oncogene homolog, human, recombinant, E. coli