H-151

SKU: orb1220798

Description

H-151 is a highly potent selective and covalent antagonist of STING reduces TBK1 phosphorylation and suppresses human STING palmitoylation.(In Vitro):H-151 (0.02-2 μM) reduces IFNβ luciferase reporter measurements of HEK293T cells.H-151 (0.5 μM; 2 h) inhibits the phosphorylation of TBK1 in THP-1 cells.H-151 (1 μM; 3 h) suppresses hsSTING palmitoylation.(In Vivo):H-151 (750 nmol per mouse; a single i.p.) markedly reduces systemic cytokine responses in CMA-treated mice.H-151 (750 nmol per mouse; i.p. daily for 7 d) exhibits notable efficacy in Trex1 / mice that expressed a bioluminescent IFNβ reporter.H-151 (750 nmol per mouse; i.p.) reaches effective systemic levels, displays a short half-life in the serum and forms an adduct to mmSTING in wild-type mice.

Key Properties

• CAS Number: 941987-60-6
• MW: 279.34
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₇N₃O?
• SMILES: CCc1ccc(NC(=O)Nc2c[nH]c3ccccc23)cc1
• Target: STING
• Solubility: DMSO:125 mg/mL (447.48 mM; Need ultrasonic)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

STING