Gypenoside XLVI

SKU: orb1304667

Description

Gypenoside XLVI

Key Properties

• CAS Number: 94705-70-1
• MW: 963.15
• Purity: 98.59%
• Formula: C₄₈H₈₂O₁₉
• SMILES: CC(C)=CCCC(C)(OC1OC(CO)C(O)C(O)C1O)C1CCC2(C)C1C(O)CC1C3(C)CC(O)C(OC4OC(CO)C(O)C(O)C4OC4OC(CO)C(O)C(O)C4O)C(C)(C)C3CCC21C
• Target: Others
• Solubility: DMSO:25 mg/mL (25.96 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.08 mM)

Bioactivity

• In Vitro:
  Gynostemma pentaphyllum (Thunb.) Makino is one o the well-known traditional Chinese herbal medicines, which has been demonstrated to be effective against chronic diseases, such as lung cancer. in the present study, seven dammarane-type compounds were isolated fro the raw, heat processed and alkaline hydrolyzed G. Pentaphyllum and compared for their cytotoxic activities against non-s All cell lung carcinoma A549 cells using MTT cytotoxicity assay. METHODS and RESULTS: By means of chemical and spectroscopic methods, their structures were established as gypenoside LVI, Gypenoside XLVI, gypenoside L, gypenoside LI, damulin A, damulin B and 20S-dammar-24-en-2α, 3β, 12β, 20-tetrol. Gypenoside LVI, Gypenoside XLVI, gypenoside L, gypenoside LI, damulin A, damulin B and 20S-dammar-24-en-2α,3β,12β,20-tetrol All showed strong cytotoxic activity against A549 cells, wit the IC50 Values of 105.8 ± .48, 52.6 ± .31, 34.9 ± .23, 50.9 ± .55, 26.9 ± .51, 4.5 ± .58, 12.5 ± .53 μg mL respectively wherea the IC50 value of 20S-Rg3 (positive control) was 55.3 ± .20 μg/ml. Comparing their structures with cytotoxic activity, these compounds might possess some kind of structure-activity relationship. CONCLUSIONS: Based o the structure and cytotoxic activity relationships of these seven constituents the OH group in C-2 the double bond in C20(21) and C20(22) positions the connected sugar number an the configuration in C-20 were important for cytotoxic activity against A549 cells.

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Gypenoside XLVI, inhibit

Compound Identifiers

PubChem CID

75090527