GW-9508

SKU: orb1307459

Description

GW9508

Research Area

Neuroscience

Key Properties

• CAS Number: 885101-89-3
• MW: 347.42
• Purity: >98%
• Formula: C₂₂H₂₁NO₃
• SMILES: O(C1=CC(CNC2=CC=C(CCC(O)=O)C=C2)=CC=C1)C3=CC=CC=C3
• Target: GPCR
• Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).

Bioactivity

• Target IC50:
  FFA1/GPR40:7.32(pEC50)|GPR120:5.46(pEC50)
• In Vivo:
  In MIN6 cells, GW9508 stimulates insulin secretion in a dose-dependent manner and enhances insulin secretion mediated by KCl. In rat β-cells, GW9508 induces hyperpolarization and the opening of KATP channels. In HaCaT cells, GW9508 inhibits the expression of IL-11, IL-24, and IL-33 induced by TNF-α and IFN-γ. Additionally, in normal human epidermal keratinocytes, GW9508 suppresses the production of CCL5 and CXCL10.
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Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-atherosclerotic, anti-inflammatory, CCL5, CXCL10, Inhibitor, IFN-γ, insulin, FFAR, FFA1, Free Fatty Acid Receptor, GW9508, GW-9508, GW 9508, GPR40(FFA1), GPR40, glucose-sensitive, GPR120, inhibit, KcsA, KATP, PotassiumChannel, Potassium Channel, TNF-α

Compound Identifiers

PubChem CID

11595431