GW806742X

SKU: orb1309591

Description

GW806742X

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 579515-63-2
• MW: 573.55
• Purity: 99.07%
• Formula: C₂₅H₂₂F₃N₇O₄S
• SMILES: CN(c1ccc(NC(=O)Nc2ccc(OC(F)(F)F)cc2)cc1)c1ccnc(Nc2cccc(c2)S(N)(=O)=O)n1
• Target: VEGFR,MLK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.97 mM);DMSO:125 mg/mL (217.94 mM)

Bioactivity

• Target IC50:
  VEGFR2:2 nM|MLKL:9.3 μM (Kd)
• In Vitro:
  GW806742X (1 μM) retards MLKL translocation to the membrane.GW806742X (0.1-10000 nM) rescues 50% of wild-type mouse dermal fibroblasts (MDFs) from TSQ-induced necroptosis with an IC50< 50 nM when 1 ng/mL TNF is used.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

membrane, Inhibitor, GW806742X, GW-806742X, HUVEC, death, necroptotic, MLKs, MLKL, Mixed Lineage Kinase, inhibit, VEGFR, VEGFR2, Vascular endothelial growth factor receptor, TSQ, translocation

Compound Identifiers

PubChem CID

5329829