GW779439X

SKU: orb1298570

Description

GW779439X is a pyrazolopyridazine inhibitor of Stk1 and Aurora kinase A (AURKA). It potentiates β-lactam antibiotics against MRSA and MSSA by inducing caspase-3/7-mediated apoptosis, as demonstrated in in vitro studies. This compound is a valuable research tool for investigating bacterial kinase pathways and antibiotic resistance mechanisms.

Research Area

Cell Biology, Epigenetics & Chromatin, Infectious Disease & Virology

Key Properties

• CAS Number: 551919-98-3
• MW: 454.45
• Purity: 99.23% (May vary between batches)
• Formula: C₂₂H₂₁F₃N₈
• SMILES: CN1CCN(CC1)c1ccc(Nc2nccc(n2)-c2cnn3ncccc23)cc1C(F)(F)F
• Target: CDK,Antibacterial,Aurora Kinase,Apoptosis
• Solubility: DMSO:4.55 mg/mL (10.01 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, AuroraKinase, Aurora Kinase, Bacterial, cancer, CDK, derivatives serine, GW779439X, GW-779439X, Inhibitor, lactam, inhibit, kinase, pazolopyridazine, threonine, Stk1, resistant

Compound Identifiers

PubChem CID

10173796