GW6471

SKU: orb1298893

Description

GW6471 is a potent PPARα antagonist (IC50 = 0.24 µM) that stabilizes co-repressor binding to the receptor. This tool compound is widely used in metabolic and cardiovascular research to inhibit PPARα-mediated transcription in both cellular and animal models.

Research Area

Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 880635-03-0
• MW: 619.67
• Purity: 98.38% (May vary between batches)
• Formula: C₃₅H₃₆F₃N₃O₄
• SMILES: CCC(=O)NC[C@H](Cc1ccc(OCCc2nc(oc2C)-c2ccccc2)cc1)N\C(C)=C/C(=O)c1ccc(cc1)C(F)(F)F
• Target: PPAR
• Solubility: DMSO:16.67 mg/mL (26.9 mM);10% DMSO+90% Saline:0.25 mg/mL (0.4 mM)

Bioactivity

• Target IC50:
  PPARγ (Cellular Binding):210 ± 64 nM|PPARα (Cellular Binding):254 ± 96 nM|PPARα (Molecular Level Binding):95.3 ± 42.0 nM|PPARγ (Molecular Level Binding):39.4 ± 18.2 nM
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• In Vivo:
  METHODS: To assay in vivo antitumor activity, GW6471 (20 mg/kg) was injected intraperitoneally every two days for four weeks into Nu/Nu mice bearing the RCC tumor Caki-1. RESULTS: In vivo treatment of xenograft mouse model with PPARα antagonist GW6471 attenuated RCC growth.
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• In Vitro:
  METHODS: RCC cells Caki-1 (VHL wild type) and 786-O (VHL mutant) were treated with GW6471 (12.5-100 µM) for 72 h. Cell viability was measured using MTT assay.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GW 6471, GW6471, GW-6471, inhibit, Inhibitor, PPARα, PPAR, Peroxisome proliferator-activated receptors

Compound Identifiers

PubChem CID

446738