GW604714X?

SKU: orb1217591

Description

GW604714X were found to be potent inhibitors of mitochondrial respiration supported by pyruvate.

Key Properties

• CAS Number: 853953-65-8
• MW: 471.46
• Purity: >98% (HPLC)
• Formula: C₂₁H₁₈FN₅O₅S
• SMILES: O=C(NC1=O)SC1=CC2=CC(C3=NC(N4CCN(C(C)=O)CC4)=CC=C3[N+]([O-])=O)=CC=C2F
• Target: Mitochondrial Metabolism
• Solubility: DMF:5mg/ml(10.61mM; need ultrasonic)

Bioactivity

• In Vitro:
  GW604714X inhibits the mitochondrial pyruvate carrier (MPC) with Ki value < 0.1 μM in direct measurement of pyruvate transport into rat liver and yeast mitochondria. Inhibitor titrations of pyruvate-dependent respiration by heart mitochondria gave values for the concentration of inhibitor binding sites and their Ki (nM) of 56.0 nM and 0.057 nM for the GW604714X. GW604714X inhibits the transport of 0.5 mM [14C]-l-lactate into rat red blood cells, mediated by the monocarboxylate transporter MCT1. GW604714X at 10 μM reduces the initial rate of uptake to 30% of control values.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-

Quick Database Links

Gene Symbol

Mitochondrial Metabolism