GW297361

SKU: orb1982259

Description

GW297361 is a potent small molecule inhibitor targeting yeast Cdk1 (IC50 = 20 nM) and Pho85 (IC50 = 400 nM). This dual activity makes it a valuable research tool for studying cell cycle regulation and phosphate metabolism signaling pathways in yeast models, both in vitro and in vivo.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 388627-21-2
• MW: 372.42
• Purity: 97.02%
• Formula: C₁₆H₁₂N₄O₃S₂
• SMILES: C(NC1=CC=C(S(N)(=O)=O)C=C1)=C2C=3C4=C(C=CC3NC2=O)N=CS4
• Target: Src,VEGFR,CDK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.69 mM);DMSO:6.25 mg/mL (16.78 mM)

Bioactivity

• Target IC50:
  VEGFR2:120 nM|CDK1 (human):30 nM|Pho85 (yeast):400 nM|CDK1 (yeast):20 nM|CDK2 (human):1.9 nM|CDK9 (human):10 nM|SRC:930 nM|CDK4 (human):300 nM
• In Vitro:
  GW297361 (20 μM; 15 min; YRP1 cells) partially inhibits intracellular Cdk1.

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CDK1, Src, VEGFR

Compound Identifiers

PubChem CID

135421144