GW280264X

SKU: orb1298489

Description

GW280264X is a potent and selective small molecule inhibitor of ADAM17 (TACE). It is widely used in biochemical and cellular research to investigate the protease's role in ectodomain shedding of TNF-α and other substrates in both in vitro and in vivo models.

Research Area

Immunology & Inflammation, Protein Biochemistry

Key Properties

• CAS Number: 866924-39-2
• MW: 575.72
• Purity: 99.51% (May vary between batches)
• Formula: C₂₈H₄₁N₅O₆S
• SMILES: CCC[C@@H]([C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)Nc1nccs1)N(O)C=O
• Target: MMP,ADAM
• Solubility: 10% DMSO+90% Corn Oil:1 mg/mL (1.74 mM);DMSO:11 mg/mL (19.11 mM)

Bioactivity

• Target IC50:
  ADAM17:8 nM (IC50)|ADAM10:11.5 nM (IC50)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TACE, stem, Matrix metalloproteinases, immunogenicity, GIC, glioblastoma, GW280264X, GW-280264X, immunotherapy, inhibit, Inhibitor, MMP, Mixed, metalloproteinases, ADAM17, ADAM10, Carbamic acid

Compound Identifiers

PubChem CID

91885425