GW 583340 dihydrochloride

SKU: orb1704493

Description

GW 583340 dihydrochloride is an orally active dual inhibitor of EGFR and ErbB2 tyrosine kinases. It reverses multidrug resistance mediated by ABCG2 and ABCB1 transporters, demonstrating potent in vitro activity against overexpressing tumor cells and significant in vivo efficacy in xenograft models.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1173023-85-2
• MW: 671.03
• Purity: 98.80% (May vary between batches)
• Formula: C₂₈H₂₇Cl₃FN₅O₃S₂
• SMILES: O=S(C)(CCNCC1=NC(C2=CC3=C(NC4=CC=C(C(Cl)=C4)OCC5=CC(F)=CC=C5)N=CN=C3C=C2)=CS1)=O.Cl.Cl
• Target: EGFR
• Solubility: DMSO:40 mg/mL (59.61 mM)

Bioactivity

• In Vitro:
  Methods: GW 583340 dihydrochloride (5 μM) was used to treat cells overexpressing ABCG2 to investigate its effects on the accumulation of anticancer substrates of ABCB1 and ABCG2 in cells overexpressing ABCB1 and ABCG2. Results: GW 583340 dihydrochloride significantly increased the intracellular level of [3H]-MX in cells overexpressing ABCG2. GW 583340 dihydrochloride (2.5 μM) reversed ABCB1- and ABCG2-mediated MDR.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GW583340, GW-583340, GW583340 dihydrochloride, GW-583340 Dihydrochloride, GW 583340, GW 583340 Dihydrochloride

Compound Identifiers

PubChem CID

16219404