GW 441756

SKU: orb1301117

Description

GW 441756 is a potent and selective small molecule inhibitor of the Tropomyosin-related kinase A (TrkA) receptor, exhibiting an IC50 of 2 nM. It is widely used in biochemical and cellular research to investigate TrkA signaling pathways in both in vitro and in vivo models of neurobiology and oncology.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 504433-23-2
• MW: 275.3
• Purity: 99.80% (May vary between batches)
• Formula: C₁₇H₁₃N₃O
• SMILES: Cn1cc(\C=C2/C(=O)Nc3cccnc23)c2ccccc12
• Target: Trk receptor,CDK,Raf,Apoptosis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.26 mM);DMSO:25 mg/mL (90.81 mM)

Bioactivity

• Target IC50:
  TrkA:2 nM
• In Vivo:
  GW441756 inhibits γH2AX production mediated by TrkA and apoptosis in cells overexpressing TrkA. It specifically blocks TrkA-induced cell death in a dose-dependent manner.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

tyrosine, Trkreceptor, TrkA, Trk Receptor, Trk receptor, Tropomyosin related kinase receptor, specific, receptor, potent, factor, growth, GW 441756, GW441756, GW-441756, Inhibitor, kinases, inhibit, NGF, nerve, Apoptosis, CDK2, C-Raf-1

Compound Identifiers

PubChem CID

9943465