GV-58

SKU: orb1309593

Description

GV-58 is a selective agonist of N- and P/Q-type voltage-gated calcium channels, with EC50 values of 7.21 µM and 8.81 µM, respectively, while exhibiting minimal activity against CDK kinases. This compound is a valuable research tool for investigating calcium channel function and neurotransmission in both cellular and animal models of neurological disorders.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1402821-41-3
• MW: 374.5
• Purity: 98.34%
• Formula: C₁₈H₂₆N₆OS
• SMILES: CCCn1cnc2c(NCc3ccc(C)s3)nc(N[C@H](CC)CO)nc12
• Target: Calcium Channel
• Solubility: DMSO:90 mg/mL (240.32 mM);Methanol:55 mg/mL (146.86 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (8.81 mM)

Bioactivity

• Target IC50:
  Ca2+ channel, N-type:7.21 uM|Ca2+ channel, P/Q-type:8.81 uM
• In Vitro:
  In comparison with the parent molecule, (R)-roscovitine, GV-58 has a 20-fold less potent cyclin-dependent kinase antagonist effect, a 3- to 4-fold more potent Ca2+ channel agonist effect, and 4-fold higher efficacy as a Ca2+ channel agonist. GV-58 had no agonist activity (up to 100 μm) on the L-type α-subunit we tested (Cav1.3).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

P-Q-type Ca2+ channel, Calcium Channel, Ca2+ channels, Ca channels, CalciumChannel, GV 58, GV58, GV-58, Inhibitor, inhibit, N- and P/Q-type Ca2+ channels, N-type Ca2+ channel

Compound Identifiers

PubChem CID

71463101