Guvacine hydrochloride

SKU: orb1299711

Description

Guvacine hydrochloride is a selective inhibitor of GABA uptake with an IC50 of 10 µM. This compound is a useful research tool for studying GABAergic neurotransmission in both in vitro and in vivo experimental models related to neuroscience and neuropharmacology.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 6027-91-4
• MW: 163.602
• Purity: 98.96% (May vary between batches)
• Formula: C₆H₁₀ClNO₂
• SMILES: Cl.OC(=O)C1=CCCNC1
• Target: GABA Receptor
• Solubility: DMSO:Slightly soluble

Bioactivity

• Target IC50:
  GABA uptake:10 μM
• In Vivo:
  In vivo, guvacine, at doses ranging from 50-100 mg/kg, decreases spontaneous activity in mice. Administration of guvacine also decreases tail flick reaction time in a rat model of morphine analgesia.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Gamma-aminobutyric acid Receptor, GABA, GABAReceptor, GABA Receptor, Guvacine, Guvacine hydrochloride, Guvacine Hydrochloride, γ-Aminobutyric acid Receptor

Compound Identifiers

PubChem CID

11957555