Gummiferin dipotassium

SKU: orb1685416

Description

Gummiferin dipotassium is an antifungal agent active against Saccharomyces cerevisiae. This small molecule is utilized in biochemical assays and serves as a valuable tool compound for antifungal drug discovery research in both in vitro and in vivo experimental models.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 33286-30-5
• MW: 847.00
• Purity: 98.00%
• Formula: C₃₁H₄₄K₂O₁₈S₂
• SMILES: C[C@]12[C@@]3([H])[C@@]4(CC[C@]1([H])C(C(O)=O)(C[C@H](C2)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)OS(=O)([O-])=O)OS(=O)([O-])=O)OC(CC(C)C)=O)C(O)=O)C[C@@](C([C@@H]4O)=C)([H])CC3.[K+].[K+]
• Target: Antifungal
• Solubility: H2O:80.00 mg/mL (94.45 mM);DMSO:20.00 mg/mL (23.61 mM)

Bioactivity

• In Vivo:
  Gummiferin dipotassium (13.5 mg/kg, intraperitoneal injection) can induce behavioral manifestations such as drowsiness, fatigue, and epileptic seizure in rats, and cause histopathological damage to the liver and kidneys, specifically manifested as hepatic cell vacuolar degeneration, necrosis, and renal tubular necrosis .
• In Vitro:
  Gummiferin dipotassium (10-25 μM, 48 hours) can induce death in mouse primary pulmonary endothelial cells and exacerbate mitochondrial dysfunction, specifically manifested as mitochondrial membrane potential depolarization, increased reactive oxygen species generation, and opening of the mitochondrial permeability transition pore . Gummiferin dipotassium (2 μM) can induce Ca²⁺ release in aged rat liver mitochondria, while triggering mitochondrial swelling and membrane potential collapse .

Storage & Handling

• Storage: keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Gummiferin, Dipotassium carboxyatractyloside

Compound Identifiers

PubChem CID

165360154