Guanfacine hydrochloride

SKU: orb1225414

Description

A selective α2A receptor agonist that can reduce peripheral sympathetic outflow and thus cansues a reduction in peripheral sympathetic tone; a sympatholytic agent used to treat hypertension and attention deficit hyperactivity disorder (ADHD).Hypertension Approved(In Vitro):Guanfacine (hydrochloride) increases the delay-related neuronal firing needed for working memory on dIPFC neurons at the cellular level.Guanfacine improves PFC cognitive function by inhibiting the production of CAMP, closing HCN channels, and strengthening the PFC networks.(In Vivo):Guanfacine (hydrochloride) enhances PFC working memory function in aged monkeys and improves impulse control in monkeys performing a delayed discounting task.Guanfacine improves cognitive performance when infused directly into the rat or monkey PFC.Guanfacine blocks 2A receptors in the monkey dIPFC markedly impairs working memory, behavioral inhibition and greatly reduces persistent neuronal firing.

Key Properties

• CAS Number: 29110-48-3
• MW: 282.5542
• Purity: >98% (HPLC)
• Formula: C₉H₁₀Cl₃N₃O
• SMILES: Cl.NC(N)=NC(=O)CC1=C(Cl)C=CC=C1Cl
• Target: Adrenergic Receptor
• Solubility: DMSO: ≥ 30 mg/mL

Bioactivity

• In Vivo:
  Guanfacine (hydrochloride) enhances PFC working memory function in aged monkeys and improves impulse control in monkeys performing a delayed discounting task. Guanfacine improves cognitive performance when infused directly into the rat or monkey PFC. Guanfacine blocks 2A receptors in the monkey dIPFC markedly impairs working memory, behavioral inhibition and greatly reduces persistent neuronal firing.
• In Vitro:
  Guanfacine (hydrochloride) increases the delay-related neuronal firing needed for working memory on dIPFC neurons at the cellular level. Guanfacine improves PFC cognitive function by inhibiting the production of CAMP, closing HCN channels, and strengthening the PFC networks.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Guanfacine

Quick Database Links

Gene Symbol

Adrenergic Receptor