Guaifenesin

SKU: orb1310335

Description

Guaifenesin is an expectorant with mild muscle relaxant properties, commonly utilized in cough formulations. In research, it is applied in respiratory studies to investigate mucolytic mechanisms and has been used in both in vitro assays and in vivo animal models of cough and airway secretion.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 93-14-1
• MW: 198.22
• Purity: 99.96%
• Formula: C₁₀H₁₄O₄
• SMILES: COC1=C(OCC(O)CO)C=CC=C1
• Target: Mucin,Others
• Solubility: DMSO:50 mg/mL (252.24 mM);H2O:23 mg/mL (116.03 mM);Ethanol:38 mg/mL (191.71 mM)

Bioactivity

• In Vivo:
  Guaifenesin (200 mg/kg, intravenously) combined with ketamine (50 mg/kg, intramuscularly) produces effective and safe surgical anesthesia for over 30 minutes in New Zealand white rabbits. Guaifenesin (200 mg/kg, intravenously) combined with ketamine (50 mg/kg, intramuscularly) mildly depresses respiratory rate but heart rate and arterial blood pressure are not significantly affected. Guaifenesin (200 mg/kg, intravenously) is combined with sodium pentobarbital (20 mg/kg, intravenously) to produce surgical anesthesia for a period of more than 30 minutes. Guaifenesin (50 mg/mL) combined Xylazine (0.1 mg/mL) and Ketamine (1.0 mg/mL) results in excellent anesthetic induction and maintenance with cardiopulmonary alterations similar to those associated with isoflurane in mechanically ventilated calves. Guaifenesin (150 mg/kg) decreases spectral edge frequency (SEF) and total power in pigs. Guaifenesin prevents adverse anesthetic induction events caused by Propofol in horse. Guaifenesin (90 mg/kg) followed by Propofol (3 mg/kg) should be sufficient to immobilize > 99% of calm healthy adult horses. Guaifenesin (100 mg/kg) produces moderate behavioral changes in the social conflict test in mice. Guaifenesin (200 mg/kg) combined with Paracetamol (200 mg/kg) causes significantly more pronounced analgesic effects that the corresponding doses of paracetamol alone in mice.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Linné, inhibit, officinale, narcotic, Inhibitor, Guaiacol glyceryl ether, Guaiphenesin, Guajacum, Guaifenesin, Glycerol guaiacolate, expectorant, cough, sputum

Compound Identifiers

PubChem CID

3516