GTP-14564

SKU: orb1737637

Description

GTP-14564 is a novel tyrosine kinase inhibitor targeting both wild-type and ITD-mutant FLT3. It demonstrates potent activity against FLT3-ITD-driven cell proliferation in vitro, requiring significantly higher concentrations to inhibit ligand-dependent wild-type FLT3 growth. This selectivity makes it a valuable research tool for studying FLT3 signaling in hematological malignancies.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 34823-86-4
• MW: 234.2527
• Purity: 99.81% (May vary between batches)
• Formula: C₁₅H₁₀N₂O
• SMILES: N1N=C(C2=C1C1=C(O2)C=CC=C1)C1=CC=CC=C1
• Target: FLT,Tyrosine Kinases
• Solubility: DMF:27 mg/mL (115.26 mM);DMSO:60 mg/mL (256.14 mM)

Bioactivity

• Target IC50:
  c-Kit:0.3 µM|PDGFRβ:1 µM|ITD-FLT3:0.3 µM|c-Fms:0.3 µM
• In Vitro:
  GTP-14564 (1 μM) inhibited the growth of interleukin-3-independent Ba/F3 expressing ITD-FLT3, whereas a 30-fold higher concentration of GTP-14564 was required to inhibit FLT3 ligand-dependent growth of Ba/F3 expressing wild type FLT3 (wt-FLT3).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tyrosine Kinases, TyrosineKinases, FLT3 (ITD), FLT3 (WT), GTP14564, GTP-14564, GTP 14564

Compound Identifiers

PubChem CID

3385203