GSK 872 hydrochloride

SKU: orb1303190

Description

GSK872 HCl（1346546-69-7 free base）

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2703752-81-0
• MW: 419.94
• Purity: 99.82%
• Formula: C₁₉H₁₈ClN₃O₂S₂
• SMILES: Cl.CC(C)S(=O)(=O)c1ccc2nccc(Nc3ccc4scnc4c3)c2c1
• Target: RIP kinase
• Solubility: DMSO:100 mg/mL (238.13 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (2.38 mM)

Bioactivity

• Target IC50:
  RIP3K:1.8 nM
• In Vivo:
  In compared with no treatment after ischemic injury in vivo, GSK872 can significantly reduce HIF-1α expression .
• In Vitro:
  GSK872 (1 μM) has no inhibition for most of 300 human protein kinases tested. It fails to inhibit RIP1 kinase. In HT-29 cells, GSK872 concentration-dependently blocks TNF-induced necroptosis. In cell-based assays, there is a 100- to 1000-fold shift in the IC50 compared to the cell-free biochemical assays. GSK872 inhibits DAI- or TLR3-induced (RIP1-independent) death. It induces caspase activation and then induces apoptotic cell death.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GSK2399872A, GSK872 HCl, GSK872 HCl(1346546 69 7 free base), GSK872 HCl(1346546697 free base), GSK-872 HCl(1346546-69-7 free base), 1346546-69-7, 1346546-69-7 free base, RIPkinase, RIP3K, RIP kinase

Compound Identifiers

PubChem CID

155971189