GSK717

SKU: orb1303680

Description

GSK717 is a potent, selective NOD2 inhibitor that disrupts its synergistic signaling with TLR2 while sparing NOD1, TNFR1, and direct TLR2 pathways. This tool compound is valuable for in vitro and in vivo research investigating NOD2's role in inflammatory and autoimmune diseases.

Research Area

Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 1595278-21-9
• MW: 452.55
• Purity: 99.01% (May vary between batches)
• Formula: C₂₈H₂₈N₄O₂
• SMILES: CN(CCc1nc2ccccc2n1CC(=O)Nc1ccc2CCCc2c1)C(=O)c1ccccc1
• Target: IL Receptor,NOD-like Receptor (NLR),NOD
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (11.05 mM);DMSO:250 mg/mL (552.43 mM)

Bioactivity

• In Vitro:
  GSK717 (5 μM) inhibits the release of IL-8, IL-6, TNFα and IL-1β in primary human monocytes stimulated with MDP. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC50 of 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cytokines, inhibit, immune, IL-8, ILReceptor, NOD2, NOD2-TLR2, NOD-like Receptor (NLR), GSK 717, GSK717, GSK-717, Inhibitor, IL Receptor, MDP-stimulated, pro-inflammatory, responses, synergy

Compound Identifiers

PubChem CID

102369397