GSK467

SKU: orb1301752

Description

GSK467 is a potent and selective KDM5/JARID1 histone demethylase inhibitor with a Ki of 10 nM. This compound is a valuable research tool for studying epigenetic regulation in cancer and development, applicable in both cellular and biochemical assays.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 1628332-52-4
• MW: 319.32
• Purity: >99.99% (May vary between batches)
• Formula: C₁₇H₁₃N₅O₂
• SMILES: O=c1[nH]c(Oc2cnn(Cc3ccccc3)c2)nc2cnccc12
• Target: Histone Methyltransferase,Histone Demethylase
• Solubility: DMSO:20.83 mg/mL (65.23 mM)

Bioactivity

• Target IC50:
  KDM5:26 nM|KDM5 (JARID1):10 nM(Ki)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GSK467, GSK-467, GSK 467, HistoneMethyltransferase, Histone Demethylase, Histone Methyltransferase, HistoneDemethylase, HCC, Inhibitor, human multiple myeloma tumor, PLU1, inhibit, JARID1B, JARID1A, anticancer

Compound Identifiers

PubChem CID

135567128