GSK3735967

SKU: orb1982524

Description

GSK3735967 is a potent, reversible, and selective non-nucleoside DNMT1 inhibitor (IC50 = 40 nM) with a planar dicyanopyridine core. It targets hemimethylated CpG sites and uniquely engages histone H4K20me3, making it a valuable chemical probe for epigenetic research in cancer and developmental biology, applicable in both cellular and biochemical assays.

Research Area

Cell Biology, Epigenetics & Chromatin

Key Properties

• CAS Number: 2170136-86-2
• MW: 477.62
• Purity: 98.11% (May vary between batches)
• Formula: C₂₅H₃₁N₇OS
• SMILES: N#CC1=C(N=C(C(C#N)=C1CC)N2CCN(C)CCC2)SCC3=CC=C(C=C3)CNC(=O)CN
• Target: Cell Cycle Arrest,Histone Methyltransferase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

132233120