GSK369796 Dihydrochloride

SKU: orb1299990

Description

GSK369796 Dihydrochloride (N-tert-butylisoquine) is a cost-effective antimalarial candidate. It demonstrates activity in malaria research and inhibits the hERG potassium channel with an IC50 of 7.5 µM, a consideration for cardiac safety profiling in preclinical development.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1010411-21-8
• MW: 428.78
• Purity: 98.00% (May vary between batches)
• Formula: C₂₀H₂₄Cl₃N₃O
• SMILES: Cl.Cl.CC(C)(C)NCc1ccc(Nc2ccnc3cc(Cl)ccc23)cc1O
• Target: Potassium Channel|||Parasite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.66 mM);DMSO:75 mg/mL (174.91 mM)

Bioactivity

• Target IC50:
  K+ channel:7.5 μM
• In Vitro:
  Analysis of antiviral activities indicated that GSK369796 has high anti-DENV activity in the DENV2 replicon expressing cells with EC50 values of 5.06 ± 0.86 μM. The infectivity assays revealed the EC50 values of 3.03 ± 0.35 μM. The mode of action of this compound is through inhibition of autophagy, thereby affecting DENV2 replication. Moreover, this compounds also showed antiviral activity against the rapidly emerging Zika virus (ZIKV) with EC50 values of 2.57 ± 0.09 μM (GSK369796).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GSK 369796, GSK 369796 Dihydrochloride, GSK369796, GSK-369796, GSK369796 Dihydrochloride, GSK-369796 Dihydrochloride, Parasite, N-tert-butylisoquine, inhibit, KcsA, Inhibitor, Potassium Channel, PotassiumChannel, potassium ion channel

Compound Identifiers

PubChem CID

51071988