GSK319347A

SKU: orb1707190

Description

GSK319347A is a potent and selective dual inhibitor of TBK1 and IKKε, also inhibiting IKK2, with demonstrated anti-tumor activity. It is a valuable research tool for studying cancers such as bladder cancer and lung adenocarcinoma in both in vitro and in vivo experimental models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 862812-98-4
• MW: 469.53
• Purity: 98.42% (May vary between batches)
• Formula: C₂₂H₁₉N₃O₅S₂
• SMILES: COc1cc2ncn(-c3cc(OCc4ccccc4S(C)(=O)=O)c(s3)C#N)c2cc1OC
• Target: IκB/IKK
• Solubility: 10% DMSO+90% Corn Oil:2 mg/mL (4.26 mM);DMSO:40 mg/mL (85.19 mM)

Bioactivity

• Target IC50:
  IKKε:469 nM|TBK1:93 nM|IKKβ:790 nM
• In Vitro:
  GSK319347A (Compound 1) inhibits the TBK1 enzyme with an IC50 of 93 nM, demonstrating good cell potency at 72 nM. Additionally, IKK-3 Inhibitor shows excellent selectivity against cell-cycle kinases CDK2 and AurB. IKK-3 Inhibitor (Compound 13) is a novel IκB kinase 2 (IKK2) inhibitor with an IC50 of 790 nM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GSK319347A, GSK-319347A, IkB/IKK, IKK, IkB, IKK2, IKK-ε, IκB, TBK1

Compound Identifiers

PubChem CID

11626927