GSK3β-IN-4

SKU: orb3174692

Description

GSK3β-IN-4 is a selective, potent, orally active ATP-competitive inhibitor of GSK3β, with an IC50 value of 0.37 nM. It also inhibits GSK3α with an IC50 of 2.75 nM and a selectivity index (SI) of 7.4. By inhibiting GSK3β, GSK3β-IN-4 reduces tau protein phosphorylation at the Ser396 site and improves cognitive deficits in Alzheimer's disease models. This compound is applicable for Alzheimer's research.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 3083425-61-7
• MW: 426.52
• Formula: C₂₆H₂₆N₄O₂
• SMILES: N(C(=O)C1CCCC1)C2=C3C(C=4C(N3)=CC(C(N[C@H](C)C5=CC=CC=C5)=O)=CC4)=CC=N2
• Target: Microtubule Associated,GSK-3

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Microtubule Associated,GSK-3