GSK3-IN-3

SKU: orb1744257

Description

GSK3-IN-3 is a neuroprotective small molecule that acts as a non-ATP competitive GSK-3 inhibitor (IC50: 3.01 µM) and a selective inducer of Parkin-dependent mitophagy. It has demonstrated protective effects in cellular models, such as against 6-OHDA toxicity, supporting its research use in studying neurodegenerative pathways.

Research Area

Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 331963-27-0
• MW: 429.55
• Purity: 98.16% (May vary between batches)
• Formula: C₂₄H₃₅N₃O₄
• SMILES: C(C)N1C=2C(C(O)=C(C(NNC(CCCCCCCCCCC)=O)=O)C1=O)=CC=CC2
• Target: Mitophagy,GSK-3
• Solubility: DMSO:3.8 mg/mL (8.85 mM)

Bioactivity

• Target IC50:
  GSK-3:3.01 μM
• In Vitro:
  GSK3-IN-3 (VP07) (25 μM; 24 h) induces mitophagy in Parkin-expressing U2OS-iMLS cells, but with limited potency. GSK3-IN-3 (1.56-25 μM; 24 h) causes mitochondrial fission and mitochondrial morphological changes in U2OS-iMLS-Parkin cells. GSK3-IN-3 (VP0.7) (5 μM, 10 μM) showed neuroprotective effects against 6-OHDA in an in vitro cellular model of Parkinson's disease in SH-SY5Y cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Mitophagy, GSK-3, GSK3

Compound Identifiers

PubChem CID

54687085