GSK3β-IN-2

SKU: orb2944637

Description

GSK3β-IN-2 (S01) is a potent GSK3β inhibitor (IC50 = 0.35 nM) that activates Wnt/β-catenin signaling to promote neurogenesis. It reduces Aβ-induced tau phosphorylation at Ser396, decreasing neurofibrillary tangles, and has been shown to ameliorate Alzheimer's-related phenotypes in a zebrafish model.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 3068378-38-8
• MW: 390.437
• Formula: C₂₅H₁₈N₄O
• SMILES: O=C(NC=1C=NC=CC1C=2C=CC=CC2)C3=CNC4=NC=C(C=C43)C=5C=CC=CC5
• Target: GSK-3,Wnt/beta-catenin

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

173640873